INGREDIENTS 

Hyaluronic acid , multivitamins (14) ,  oligoelements (10), multiaminoacids (24), coenzyme A, nicotinamide adenine dinucleotide NAD, thiamine diphosphate (cocarboxhylase), disodium flavine adenine dinucleotide, nucleic acids (6),  ALA (sodium R-alpha-Lipoate), glutathione, D.M.A.E. , 2 more key ingredients and 9 Biomimetic Peptides:

COSMECEUTIC AND THERAPEUTIC DIRECTIONS 

As the skin ages, collagen deposits in the lower layers of skin begin to breakdown and the skin is unable to replace them. As this happens, the specific cells of the skin lose their elasticity causing the skin to stretch and sag from the face. As it stretches and sags, it is wrinkled and loose, sometimes hanging under the chin, around the eyes, and under the cheeks. This is one of the tell-tale signs of aging and one of the hardest to fight without cosmetic surgery.

This biotech product shows remarkable effect at stimulating cellular proliferation and extra cellular matrix synthesis. It gets rid of this skin aged appearance recovering its elasticity, vitality and smoothness.

It is also important to stress on the extraordinary effect at boosting collagen and elastin by fibroblasts and also cell regeneration.

*These are advisable therapeutic uses, but the ingredients of products may allow a physician to apply them under professional criteria, may find the product optimal to treat other aesthetic issues.

 

CLINICAL DATA

 Pharmacology  

Pharmacology of the actives compounds in the formula which promotes antiaging effect:

DMAE:

• The acute skin-firming effects of DMAE have been confirmed by quantitative measures of cutaneous tensile strength. Although its mechanisms of action in the skin remain to be elucidated, evidence suggests that the skin is an active site of acetylcholine synthesis, storage, secretion, metabolism, and receptivity. Muscarinic acetylcholine receptors have been localized to keratinocytes, melanocytes and dermal fibroblasts, whereas nicotinic acetylcholine receptors have been found in keratinocytes. 
• DMAE is an analog of the B vitamin choline and is a precursor of acetylcholine, the firming action of DMAE is explained by the fact that its molecule, considered to be a precursor of acetylcholine, alters muscle contraction.
• The benefits of DMAE in dermatology include a potential anti-inflammatory effect and a documented increase in skin firmness with possible improvement in underlying facial muscle tone.
• It is demonstrated the activity over muscle fibers improving their firmness and  thus gives tone to the skin.

• The appearance of prematurely aged skin is a phenomenon characterized by progressive alteration of the dermal extracellular matrix, including elastin and collagen fibers. This substance improves the appearance of photoaged skin, due to the ability to induce molecular responses associated with wrinkle effacement, particularly increased collagen production.
• Due to its proved antioxidant property, reduces the outcome of fine wrinkles,  also gets down hyperpigmentation and enhance skin firmness and elasticity. On the other hand it shows excellent hydration attribute.

• Improves cell adhesion by enhancing synthesis of laminin-5.
• Adhesion of cells to the basement membrane and among themselves provides firmness to the skin.
• Increases contact between skin cells ensures correct nourishment and health.
• Induces a significant increase in dermis density, improving skin compactness. 

• Another of Relistase’s benefits is its ability to encourage collagen production.
• The main function of Relistase, however, is to tighten the look skin.

• A stabilized peptide engineered for cutaneous delivery that is resistant to enzyme degradation. It mimics TGF-β β by activation of the transforming growth factor-ββ receptor Type II (TβRII) to activate collagen synthesis. In consequence, it reduces wrinkles by increasing collagen in the skin.
• It works by turning on the gene responsible for the production of collagen.
• Reduction in wrinkles in 28 days (In-vivo).
• Increase in Collagen I Synthesis (in-vitro).
• Increase in Collagen III Synthesis (In-vitro).

• It consists of a short chain of three amino acids ( glycine-histidine-lysine) connected to palmitic acid.. This peptide  is a fragment of type I collagen molecule and is believed to serve as a biological increase degradation signal of the skin matrix. Indeed, when collagen is degraded, more of its small fragments get created in the body, including GHK fragment. When the key skin matrix-producing cells (fibroblasts) detect increased levels of GHK, they “assume” that the skin matrix is being lost at a higher rate and begin synthesizing it more vigorously. Thus, Pal-GHK is intended to stimulate skin matrix, leading  to wrinkle reduction, skin firming and other aesthetic benefits.
• Another interesting point about this peptide fragment, is that it is a part of another well known skin care ingredient, the copper peptide Cu-GHK. Copper peptides are known to improve wound healing, activate skin remodeling, improve the structure of skin matrix, reduce scarring and exert other beneficial effects on the skin.

• Palmitoyl tetrapeptide consists of a short chain of four amino acids (a.k.a. GQPR peptide or glycine-glutamine-proline-arginine) connected to palmitic acid. 
• Palmitoyl tetrapeptide is believed to work by reducing the production of interleukin-6 (IL-6) by the the key skin cells, keratinocytes and fibroblasts. IL-6 is a molecule that promotes inflammation, which, in turn, leads to faster degradation of the skin matrix and thus contributes to the development of wrinkles and loss of skin firmness and elasticity. By reducing the levels of IL-6 and possibly other inflammation mediators, palmitoyl tetrapeptide-7 is thought to slow down the degradation of the skin matrix and may also stimulate its replenishment. 

• This peptide will affect the six major structural components of the skin to stimulate collagen and diminish or even prevent fine lines, increase hydration levels, and protect and repair damaged skin.
  The dermal-epidermal junction (DEJ) is where the epidermis, the top layer of the skin, meets the dermis, the lower layers of the skin. There is no blood flow in the dermis, so it relies on the epidermis for nourishment and protection. The epidermis sends efficacious ingredients from skin care products to the dermis through collagen channels. Palmitoyl tripeptide-38  strengthens collagen; thereby, enhancing the communication between the epidermis and dermis. This helps to create a fresh, youthful and glowing complexion.

• Reduces and prevents lines and wrinkles by actively generating new skin cells.
• Involves in normal skin growth, healing and wound repair.
• Strengthens skin elasticity by inducing the synthesis of collagen and elastin.
• More stable and prolonged action than native proteins.
• It has showed positive regulation of collagen expression.
• Increases fibroblast cell and keratinocyte cell proliferation in dose-dependent manner.
• This olygopeptide shows great effect anti-wrinkle and skin tightening. 

• Proven anti-aging and wrinkle smoothing peptide. This peptide increases the thickness of the epidermis and dermis, increases skin elasticity, and reduces wrinkles, resulting in a removal of skin imperfections such as blotchiness and sun damage marks, while producing a significant increase in subcutaneous fat cells. 

• It has been demonstrated, this molecule strengthens skin elasticity by inducing collagen and elastin synthesis.
• Involves in normal skin growth, healing and wound repair.
• Reduces and prevents lines and wrinkles by actively gernerate new skin cells.
• Cell attachment is essential for cells survival and this oligopeptide shows great cell attachment enhacement.
• Antiapoptosis of keratinocytes. 

• Reduces and prevents lines and wrinkles by actively generating new skin cells.
• Enhances skin tone that brimming with vitality and energy.
• Minimize scars on skin by forming new skin cell.
• Up-regulation of cell growth and migration, cell survival, extracellular matrix expression.
• Cell Proliferation with Keratinocyte and Fibroblast Cells.
• Increases fibroblasts and keratinocytes proliferation in dose-dependent manner.
• It has showed positive regulation of Hyaluronic acid and Fibronectin expression. Increased expression of hyaluronic acid (3 folds) and Elastin (1.3 fold) was observed in dose-dependent manner in fibroblast cell.
• This molecule increases cell survival of keratinocytes cell line by its anti apoptosis attribute, also enhances the attachment of cell by means of EGF, growing epidermic factor regulation.

 Posology and way of administration 

They should be done by the supervision of a doctor or a registered nurse and they will apply the best technique available in each case.

The product is developed sterile, preservative free and pyrogen free to be used on several aesthetic techniques, IPL, roller and other invasive or non invasive procedures.